Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13616861 | 0.82 | PIM1 (0.40) | EPHB4MEN1MAPTKMT2AIDO1 | |
| SCHEMBL13616805 | 0.77 | MPL (0.47) | DPP4KDM4EALDH1A1MAP4K4 | |
| SCHEMBL13398672 | 0.75 | KDM4E (0.50) | CYP3A4KDM4EALDH1A1LMNAGRM4 | |
| SCHEMBL13617070 | 0.72 | GRM2 (0.37) | MEN1KMT2AKDM4E | |
| SCHEMBL13616809 | 0.71 | DHFR (0.47) | DPP4MAP4K4 | |
| SCHEMBL13616971 | 0.71 | MPL (0.38) | CYP3A4KDM4EALDH1A1LMNALRRK2 | |
| SCHEMBL13617343 | 0.70 | ALDH1A1 (0.43) | DPP4TSHRKDM4EALDH1A1LMNA | |
| SCHEMBL13616949 | 0.70 | MAP4K4 (0.44) | EPHB4DPP4CYP3A4LMNAMAP4K4 | |
| SCHEMBL13398594 | 0.68 | GABRG2 (0.43) | HTTMEN1MAPTKMT2AKDM4E | |
| SCHEMBL1802577 | 0.68 | MPL (0.65) | MEN1MAPTKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119716-A1 | AZA-BRIDGED-RING COMPOUND | Astellas Pharma Inc. (JP) | 2009-11-18 | — | — | EP | disclosed |