Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215974 | 0.82 | TYR (0.49) | CNR2TYRPOLBALDH1A1KMT2A | |
| SCHEMBL217818 | 0.80 | CNR2 (0.53) | CNR2TYRPOLBALDH1A1KMT2A | |
| SCHEMBL217912 | 0.71 | CNR2 (0.44) | CNR2TYRPOLBALDH1A1KMT2A | |
| Dimethylamine SCHEMBL218292 | 0.68 | CNR2 (0.42) | CNR2TYRPOLBALDH1A1KMT2A | |
| SCHEMBL2141794 | 0.67 | GPR84 (0.39) | CNR2TYRPOLBALDH1A1KMT2A | |
| SCHEMBL216349 | 0.66 | TYR (0.43) | CNR2TYRTLR8 | |
| SCHEMBL19164856 | 0.66 | ALDH1A1 (0.48) | CNR2TYRPOLBALDH1A1KMT2A | |
| SCHEMBL8630383 | 0.65 | TLR8 (0.33) | TYRKMT2ATLR8 | |
| SCHEMBL18625864 | 0.65 | KMT2A (0.37) | TYRPOLBALDH1A1KMT2ALMNA | |
| SCHEMBL587358 | 0.64 | LPO (0.50) | CNR2TYRPOLBALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1477186-B1 | ANTIPRURITICS | SHIONOGI & CO (JP) | 2009-11-11 | — | — | EP | disclosed |