Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13617213 | 0.75 | CPB2 (0.33) | CPB2 | |
| SCHEMBL3889533 | 0.74 | CPB2 (0.56) | HDAC1HDAC3HDAC2NCOR2CPB2 | |
| SCHEMBL3845420 | 0.73 | CPB2 (0.46) | HDAC1HDAC3HDAC2NCOR2CPB2 | |
| SCHEMBL13617413 | 0.70 | HDAC3 (0.53) | HDAC1HDAC3HDAC2NCOR2NPC1 | |
| SCHEMBL6379732 | 0.70 | HDAC1 (0.53) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL6378615 | 0.69 | HDAC1 (0.52) | HDAC1HDAC3HDAC2NCOR2MAPK1 | |
| SCHEMBL5122254 | 0.69 | HDAC3 (0.51) | HDAC1HDAC3HDAC2NCOR2ALDH1A1 | |
| SCHEMBL8525848 | 0.69 | HDAC3 (0.56) | HDAC1HDAC3HDAC2NCOR2LMNA | |
| SCHEMBL7202284 | 0.69 | HDAC3 (0.54) | HDAC1HDAC3HDAC2NCOR2LMNA | |
| SCHEMBL4137813 | 0.69 | HDAC3 (0.51) | HDAC1HDAC3HDAC2NCOR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311488-B1 | SUBSTITUTED IMIDAZOLES AS TAFIA INHIBITORS | PFIZER LTD (GB) | 2009-11-04 | — | — | EP | disclosed |