Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 9/20 | 0.37 |
| ▸ | HTR1A | P08908 | 8/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 8/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1383623 | 0.93 | TSHR (0.43) | TSHRL3MBTL1ADRA1AHTR1AADRA1D | |
| SCHEMBL2831365 | 0.89 | ALDH1A1 (0.40) | TSHRL3MBTL1ADRA1AHTR1AADRA1D | |
| SCHEMBL1380766 | 0.88 | BRD4 (0.38) | TSHRL3MBTL1ADRA1AHTR1AADRA1D | |
| SCHEMBL13617548 | 0.87 | CYP1A2 (0.38) | HTR1AALDH1A1 | |
| SCHEMBL1382684 | 0.87 | ALDH1A1 (0.48) | L3MBTL1ADRA1AHTR1AADRA1DADRA1B | |
| SCHEMBL2829817 | 0.86 | TSHR (0.35) | TSHRL3MBTL1ADRA1AHTR1AADRA1D | |
| SCHEMBL2832891 | 0.80 | DRD2 (0.41) | TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL2834166 | 0.80 | HTR1A (0.38) | L3MBTL1ADRA1AHTR1AADRA1DADRA1B | |
| SCHEMBL1381520 | 0.80 | ALDH1A1 (0.43) | L3MBTL1ADRA1AHTR1AADRA1DADRA1B | |
| SCHEMBL1382661 | 0.79 | MTNR1A (0.43) | TSHRADRA1AHTR1AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888538-B1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-(2-ARYLOXY-ETHYL)-AMINES HAVING AN ACTIVITY ON THE 5-HT RECEPTOR | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | disclosed |