Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | CNR2 | P34972 | 4/20 | 0.55 |
| ▸ | CNR1 | P21554 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13991203 | 0.89 | CNR2 (0.65) | MEN1KMT2ACNR2CNR1USP2 | |
| SCHEMBL2736550 | 0.83 | L3MBTL1 (0.60) | MEN1KMT2ACNR2CNR1L3MBTL1 | |
| SCHEMBL13991132 | 0.83 | MEN1 (0.66) | MEN1KMT2ACNR2CNR1L3MBTL1 | |
| SCHEMBL2736723 | 0.78 | CNR2 (0.80) | MEN1KMT2ACNR2CNR1LMNA | |
| SCHEMBL2736714 | 0.78 | CNR2 (0.70) | MEN1KMT2ACNR2CNR1LMNA | |
| SCHEMBL11534161 | 0.76 | LMNA (0.48) | MEN1KMT2ACNR2CNR1L3MBTL1 | |
| SCHEMBL2736779 | 0.76 | CNR2 (0.73) | MEN1KMT2ACNR2CNR1SMN1; SMN2 | |
| SCHEMBL11536142 | 0.76 | MAPT (0.51) | MEN1KMT2AKDM4EHSD17B10TAAR1 | |
| SCHEMBL2736725 | 0.74 | CNR2 (0.61) | MEN1KMT2ACNR2CNR1L3MBTL1 | |
| SCHEMBL2736719 | 0.74 | CNR2 (0.66) | MEN1KMT2ACNR2CNR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1477186-B1 | ANTIPRURITICS | SHIONOGI & CO (JP) | 2009-11-11 | — | — | EP | disclosed |
| US-20080312292-A1 | Antipruritics | YASUI KIYOSHI | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312292-A1 | Antipruritics | CNR1, CNR2, OPRL1 | MEN1 4507/4885KMT2A 2819/4885CNR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.