Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13617534 | 1.00 | MAPT (0.32) | MAPTHTTGFERSMN1; SMN2SETD7 | |
| SCHEMBL13617489 | 1.00 | MAPT (0.32) | MAPTHTTGFERSMN1; SMN2SETD7 | |
| SCHEMBL3380170 | 1.00 | MAPT (0.32) | MAPTHTTGFERSMN1; SMN2SETD7 | |
| SCHEMBL3382259 | 0.86 | TRPA1 (0.40) | — | |
| SCHEMBL3384341 | 0.83 | CHRNA7 (0.36) | MAPTSETD7 | |
| SCHEMBL3380168 | 0.80 | SETD7 (0.30) | SETD7 | |
| SCHEMBL3381668 | 0.80 | SETD7 (0.35) | SETD7 | |
| SCHEMBL3383083 | 0.80 | SETD7 (0.35) | SETD7 | |
| SCHEMBL3385842 | 0.79 | MEN1 (0.36) | SMN1; SMN2SETD7 | |
| SCHEMBL3384775 | 0.79 | BRD4 (0.37) | SETD7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275610-A1 | TRICYCLIC OPIOID MODULATORS | DECORTE BART | 2009-11-05 | — | — | US | disclosed |
| US-7582650-B2 | Tricyclic opioid modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275610-A1 | TRICYCLIC OPIOID MODULATORS | OPRD1, OPRM1, OPRK1 | MAPT 1747/4885HTT 3367/4885GFER 3252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.