SCHEMBL13618560

SCHEMBL13618560

CC(C)(C)c1cc(-c2nc(C(C)(I)I)no2)on1

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 2/20 0.35
ALDH1A1 P00352 1/20 0.33
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
CNR2 P34972 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10146108 0.88 PIK3CG (0.44) PIK3CGALDH1A1NPC1RAB9AL3MBTL1
SCHEMBL10147494 0.74 CNR2 (0.30) NPC1RAB9ACNR2
SCHEMBL13618545 0.73 ALDH1A1 (0.32) ALDH1A1
SCHEMBL350900 0.73 PTGS2 (0.36) PIK3CGALDH1A1L3MBTL1CNR2
SCHEMBL13618561 0.71 ALDH1A1 (0.34) ALDH1A1CNR2
SCHEMBL10147513 0.70 CNR2 (0.35) CNR2
SCHEMBL13534490 0.69 ALDH1A1 (0.41) ALDH1A1NPC1RAB9ACNR2
SCHEMBL10146116 0.67 CYP1A2 (0.37) ALDH1A1CNR2
SCHEMBL10147474 0.67 ALDH1A1 (0.32) ALDH1A1
SCHEMBL13618722 0.66 ALDH1A1 (0.34) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009140089-A2 SULFONE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-11-19 WO disclosed