Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20033605 | 0.79 | MAPK14 (0.36) | LMNAPOLBMEN1KMT2ABRAF | |
| SCHEMBL12338356 | 0.78 | LMNA (0.42) | LMNAL3MBTL1BRAFTNNI3KALDH1A1 | |
| SCHEMBL4420113 | 0.77 | S1PR3 (0.47) | LMNAKDM4EMAPK1 | |
| SCHEMBL19119211 | 0.75 | POLB (0.59) | LMNAPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL2825786 | 0.75 | ALDH1A1 (0.62) | LMNAPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL4901604 | 0.74 | CA2 (0.50) | LMNAPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL3874483 | 0.74 | MAPK1 (0.46) | LMNAPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL12225751 | 0.74 | HSD17B10 (0.54) | LMNAPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL13543494 | 0.74 | CYP3A4 (0.52) | LMNAPOLBL3MBTL1MEN1KMT2A | |
| SCHEMBL4844487 | 0.74 | KMT2A (0.50) | LMNAPOLBL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848694-B1 | HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 | HOFFMANN LA ROCHE (CH) | 2009-11-25 | — | — | EP | disclosed |