Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.40 |
| ▸ | GSK3B | P49841 | 4/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19816123 | 0.73 | ULK1 (0.43) | ULK1DYRK1AGSK3BROCK2WNT1 | |
| SCHEMBL5190435 | 0.69 | ADORA1 (0.45) | ULK1DYRK1AGSK3BWNT1POLB | |
| SCHEMBL15219344 | 0.69 | GSK3B (0.42) | ULK1DYRK1AGSK3BWNT1SMN1; SMN2 | |
| SCHEMBL1553389 | 0.68 | ROCK2 (0.61) | ULK1DYRK1AROCK2SIRT2FLT3 | |
| SCHEMBL5190502 | 0.68 | ROCK2 (0.44) | ULK1DYRK1AGSK3BROCK2WNT1 | |
| SCHEMBL11915928 | 0.67 | FLT3 (0.42) | ULK1DYRK1AGSK3BWNT1SIRT2 | |
| SCHEMBL5897586 | 0.67 | SMN1; SMN2 (0.84) | POLBSMN1; SMN2NPC1RAB9ATDP1 | |
| SCHEMBL5264885 | 0.67 | ULK1 (0.41) | ULK1HRH3DYRK1AGSK3BROCK2 | |
| SCHEMBL4141969 | 0.67 | HPGD (0.69) | ULK1POLBSIRT2SMN1; SMN2NPC1 | |
| SCHEMBL6735320 | 0.67 | ROCK2 (0.44) | ULK1DYRK1AGSK3BROCK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365809-B1 | PYRAZINOPYRAZINES AND DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMA INC (US) | 2018-07-18 | — | — | EP | disclosed |
| WO-2009143389-A1 | PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | WO | disclosed |