Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28642118 | 0.87 | KCNA3 (0.40) | ALDH1A1LMNACHRNB2CHRNA4 | |
| SCHEMBL6461377 | 0.83 | KMT2A (0.55) | POLB | |
| SCHEMBL8324608 | 0.81 | CYSLTR1 (0.49) | TP53CYP3A4ALDH1A1SMN1; SMN2LMNA | |
| Acetonitrile SCHEMBL10585019 | 0.80 | ALDH1A1 (0.38) | TP53ALDH1A1SMN1; SMN2MAOBLMNA | |
| SCHEMBL9900879 | 0.78 | IDO1 (0.43) | MAOB | |
| SCHEMBL2207774 | 0.76 | NOS3 (0.44) | ALDH1A1TSHRSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL2207957 | 0.75 | TSHR (0.43) | ALDH1A1TSHRSMN1; SMN2MAPK1NPSR1 | |
| SCHEMBL7706827 | 0.74 | CA1 (0.50) | TP53CYP3A4ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL3189738 | 0.74 | L3MBTL1 (0.37) | MAOBLMNAMAPK1CHRNB2CHRNA4 | |
| SCHEMBL1284441 | 0.74 | RAB9A (0.48) | ALDH1A1SMN1; SMN2MAOBLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615543-B2 | Complexes with C-reactive protein (CRP) molecules; rheumatoid arthritis, juvenile chronic (rheumatoid) arthritis, ankylosing spondylitis, psoriatic arthritis, systemic vasculitis, polymyalgia rheumatica, Reiter's disease, Crohn's disease and familial Mediterranean fever | PENTRAXIN THERAPEUTICS LIMITED (GB) | 2009-11-10 | — | — | US | disclosed |