Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL169873 | 0.86 | ALDH1A1 (0.59) | ALDH1A1CTSLSMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL14817498 | 0.81 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2HTTL3MBTL1GAA | |
| SCHEMBL172001 | 0.79 | HDAC4 (0.50) | ALDH1A1SMN1; SMN2HTTL3MBTL1HDAC4 | |
| SCHEMBL14019859 | 0.76 | EPHX1 (0.56) | ALDH1A1SMN1; SMN2HTTL3MBTL1GAA | |
| SCHEMBL13620071 | 0.74 | GAA (0.51) | ALDH1A1SMN1; SMN2HTTL3MBTL1GAA | |
| SCHEMBL19531832 | 0.74 | ALDH1A1 (0.79) | ALDH1A1CTSLSMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL31445283 | 0.73 | ALDH1A1 (0.54) | ALDH1A1CTSLSMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL17993499 | 0.72 | HDAC4 (0.53) | ALDH1A1SMN1; SMN2HTTL3MBTL1GAA | |
| SCHEMBL24571257 | 0.72 | THRB (0.51) | ALDH1A1HTTL3MBTL1GAAALPL | |
| SCHEMBL2363240 | 0.71 | HDAC4 (0.59) | ALDH1A1SMN1; SMN2HTTL3MBTL1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286984-A1 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | Mirati Therapeutics, Inc. | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286984-A1 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | MAP3K19, MAP3K9, MAP4K2 | ALDH1A1 3152/4885CTSL 4233/4885SMN1; SMN2 3577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.