Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.36 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12309248 | 0.79 | LMNA (0.40) | MAPK1KDRCDK5AURKBCLK4 | |
| SCHEMBL855351 | 0.77 | CYP1A2 (0.43) | MAPK1KDRCDK5AURKBCLK4 | |
| SCHEMBL13607880 | 0.76 | ALPL (0.38) | ALPLMAPK1KDRCDK5AURKB | |
| SCHEMBL29124653 | 0.75 | KDM5A (0.36) | ALPLMAPK1KDRCDK5AURKB | |
| SCHEMBL14770635 | 0.73 | DYRK1B (0.38) | MAPK1CDK5AURKBCLK4AURKA | |
| SCHEMBL13607760 | 0.71 | PTGES (0.51) | MAPK1KDRCDK5AURKBCLK4 | |
| SCHEMBL14770725 | 0.69 | MEN1 (0.39) | MAPK1CDK5AURKBCLK4AURKA | |
| SCHEMBL31588150 | 0.68 | SMN1; SMN2 (0.53) | MAPK1KDRCDK5AURKBCLK4 | |
| SCHEMBL1192302 | 0.68 | SMN1; SMN2 (0.53) | MAPK1KDRCDK5AURKBCLK4 | |
| SCHEMBL13607779 | 0.68 | GAA (0.50) | KDRCDK5AURKBCLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622479-B2 | Bicyclic derivative, its production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |