Sugi Predict

Sugi Predict / Compounds / SCHEMBL1362046

SCHEMBL1362046

SCHEMBL1362046

COC(=O)CCc1ccccc1OCCCc1oc(-n2ccnc2C)nc1-c1ccc(Cl)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PPARD Q03181 5/20 0.36
▸ DHFR P00374 1/20 0.35
▸ TP53 P04637 1/20 0.34
▸ MEN1 O00255 3/20 0.33
▸ KMT2A Q03164 3/20 0.33
▸ CYP1A2 P05177 2/20 0.33
▸ CYP3A4 P08684 2/20 0.33
▸ CYP2C9 P11712 2/20 0.33
▸ CYP2C19 P33261 2/20 0.33
▸ ALDH1A1 P00352 2/20 0.33
▸ MAPT P10636 2/20 0.33
▸ KDM4E B2RXH2 2/20 0.33
▸ USP2 O75604 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ CETP P11597 1/20 0.33
▸ THRB P10828 1/20 0.33
▸ TAAR1 Q96RJ0 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ PPARG P37231 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1362894 0.92 RXRA (0.41) PPARDDHFRPPARGFFAR4
SCHEMBL1361184 0.88 PPARD (0.35) PPARDDHFRTP53MEN1KMT2A
SCHEMBL6603683 0.87 ALDH1A1 (0.39) MEN1KMT2ACYP1A2CYP3A4CYP2C9
SCHEMBL1360319 0.86 TP53 (0.38) TP53MEN1KMT2AALDH1A1MAPT
SCHEMBL962882 0.85 MAPT (0.36) TP53MEN1KMT2ACYP1A2CYP3A4
SCHEMBL1361779 0.84 GCGR (0.34) PPARDTP53ALDH1A1MAPTLMNA
SCHEMBL203742 0.84 TP53 (0.41) TP53MEN1KMT2AALDH1A1MAPT
SCHEMBL1361746 0.83 GCGR (0.38) TP53MEN1KMT2ACYP1A2CYP3A4
Hydrochloric Acid SCHEMBL1362475 0.83 TP53 (0.41) TP53MEN1KMT2AALDH1A1MAPT
SCHEMBL1361418 0.83 MAPT (0.42) TP53MEN1KMT2ACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8067453-B2 Oxazole compound to treat or prevent diabetic neuropathy; 4-(4-chlorophenyl)-5-(3-(2-methoxyphenoxy)propyl-2-methyl-1-imidazolyl)oxazole TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-11-29 — — US disclosed
US-20080269219-A1 Neurotrophin production/secretion promoting agent TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-10-30 — — US disclosed
US-7396848-B1 oxazole derivatives to treat diabetic neuropathy and/or other kinds of peripheral neuropathy; 4-(4-chlorophenyl)-5-[3-(2-methoxyphenoxy)propyl]-2-(2-methyl-1-imidazolyl)oxazole TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-07-08 — — US disclosed
EP-1206472-B1 OXAZOLE AND THIAZOLE DERIVATIVES AS NEUROTROPHIN PRODUCTION/SECRETION PROMOTING AGENT TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-10-01 — — EP disclosed
US-6605629-B1 Oxazole derivatives; low toxicity TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-08-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080269219-A1 Neurotrophin production/secretion promoting agent BDNF, NGF, NTRK2 PPARD 2505/4885DHFR 2781/4885TP53 4289/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.