Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18202930 | 0.85 | HRH3 (0.33) | HRH3OPRM1OPRK1OPRL1 | |
| SCHEMBL15806910 | 0.84 | ALDH1A1 (0.41) | ALDH1A1HRH3L3MBTL3L3MBTL1NCF1 | |
| SCHEMBL13963039 | 0.83 | ALDH1A1 (0.36) | ALDH1A1HRH3L3MBTL3L3MBTL1NCF1 | |
| SCHEMBL14996489 | 0.82 | ALDH1A1 (0.38) | ALDH1A1HRH3L3MBTL3L3MBTL1NCF1 | |
| SCHEMBL12774192 | 0.82 | HRH3 (0.37) | ALDH1A1HRH3L3MBTL3L3MBTL1OPRM1 | |
| SCHEMBL8314294 | 0.81 | SIGMAR1 (0.37) | HRH3OPRL1 | |
| SCHEMBL6889567 | 0.80 | HRH3 (0.42) | ALDH1A1HRH3L3MBTL3L3MBTL1NCF1 | |
| SCHEMBL26042916 | 0.80 | L3MBTL3 (0.47) | ALDH1A1L3MBTL3L3MBTL1NCF1GAA | |
| SCHEMBL24697452 | 0.79 | HRH3 (0.32) | HRH3OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL22565087 | 0.78 | HRH3 (0.36) | ALDH1A1HRH3L3MBTL3L3MBTL1NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023088477-A1 | MULTIFUNCTIONAL COMPOUND CAPABLE OF DEGRADING BTK KINASE, AND COMPOSITION AND USE | 杭州和正医药有限公司 | 2023-05-25 | — | — | WO | disclosed |
| WO-2023274390-A1 | BRUTON'S TYROSINE KINASE AND MUTANT DEGRADER, COMPOSITION AND APPLICATION THEREOF | 杭州和正医药有限公司 | 2023-01-05 | — | — | WO | disclosed |
| WO-2009141532-A2 | PYRROLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2009-11-26 | — | — | WO | disclosed |