Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.74 |
| ▸ | MIF | P14174 | 1/20 | 0.74 |
| ▸ | HTR2A | P28223 | 1/20 | 0.74 |
| ▸ | HTR2B | P41595 | 1/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11590544 | 0.88 | ADRB1 (0.69) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| SCHEMBL6843601 | 0.85 | ADRA1A (0.54) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL136778 | 0.85 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL29379078 | 0.85 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL11417827 | 0.85 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL3148045 | 0.85 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL19169701 | 0.85 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL31144506 | 0.85 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL5172992 | 0.85 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| Metaraminol SCHEMBL4262898 | 0.85 | ADRB1 (1.00) | ADRB1ADRA1AMIFHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137411-A1 | THERAPEUTIC COMPOUNDS | ALLERGAN, INC. (US) | 2009-11-12 | — | — | WO | disclosed |