Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13622809 | 0.88 | KMT2A (0.44) | ALDH1A1KMT2AMEN1POLBTSHR | |
| SCHEMBL2090738 | 0.88 | KMT2A (0.44) | ALDH1A1KMT2AMEN1POLBTSHR | |
| SCHEMBL2096559 | 0.86 | KMT2A (0.42) | ALDH1A1KMT2AMEN1POLBTSHR | |
| SCHEMBL8004907 | 0.85 | HRH3 (0.36) | SLC6A4SLC6A2SLC6A3KCNH2ALDH1A1 | |
| SCHEMBL13622767 | 0.80 | SLC6A4 (0.34) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL8003405 | 0.80 | KMT2A (0.43) | SLC6A4SLC6A2SLC6A3KCNH2ALDH1A1 | |
| SCHEMBL8002704 | 0.79 | HTR6 (0.41) | SLC6A4SLC6A2SLC6A3KCNH2ALDH1A1 | |
| SCHEMBL3118867 | 0.78 | SIGMAR1 (0.44) | SLC6A4SLC6A2SLC6A3KCNH2ALDH1A1 | |
| SCHEMBL27624686 | 0.77 | SLC6A4 (0.42) | SLC6A4SLC6A2SLC6A3KCNH2EPHX1 | |
| SCHEMBL16795227 | 0.76 | SLC6A4 (0.44) | SLC6A4SLC6A2SLC6A3KCNH2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136850-A1 | MUSCARINIC RECEPTOR AGONITS USEFUL IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA | ASTRAZENECA AB (SE) | 2009-11-12 | — | — | WO | disclosed |