Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 5/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 13/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | USP7 | Q93009 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13623919 | 0.78 | MAPK10 (0.67) | SMOMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL3145419 | 0.78 | NR3C1 (0.63) | — | |
| SCHEMBL13624667 | 0.77 | MAPK10 (0.51) | SMOMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL13624505 | 0.76 | MAPK10 (0.55) | SMOMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL13624133 | 0.75 | MAPK10 (0.54) | SMOMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL1402717 | 0.73 | BRD4 (0.55) | MAPK10MAPK8BRD4 | |
| SCHEMBL13623901 | 0.73 | MAPK10 (0.56) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL13624663 | 0.72 | MAPK10 (0.49) | SMOMAPK10MAPK8 | |
| SCHEMBL13623928 | 0.71 | MAPK10 (0.48) | SMOMAPK10MAPK8MAPK13MAPK12 | |
| SCHEMBL13623899 | 0.71 | MAPK10 (0.57) | MAPK10MAPK8MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142569-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | WO | disclosed |