Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 14/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | POLR1A | O95602 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13623899 | 0.86 | MAPK10 (0.57) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL13623919 | 0.82 | MAPK10 (0.67) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL13624505 | 0.80 | MAPK10 (0.55) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL13624133 | 0.79 | MAPK10 (0.54) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL3149920 | 0.77 | NR3C1 (0.66) | — | |
| SCHEMBL13624667 | 0.77 | MAPK10 (0.51) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL13624506 | 0.73 | SMO (0.48) | MAPK10MAPK8MAPK13MAPK12MAPK11 | |
| SCHEMBL13624663 | 0.72 | MAPK10 (0.49) | MAPK10MAPK8KMT2AHPGDSKDM4E | |
| SCHEMBL1402380 | 0.72 | RAB9A (0.76) | RAB9AKMT2AHPGDSKDM4EALDH1A1 | |
| SCHEMBL18013554 | 0.72 | NR3C1 (0.55) | MAPK10MAPK8MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142569-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | WO | disclosed |