Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 17/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4300547 | 0.85 | HTR6 (0.53) | TP53CREBBPHTR6PTGS1PTGS2 | |
| SCHEMBL30223561 | 0.73 | KDM4E (0.66) | TP53CREBBP | |
| SCHEMBL22118133 | 0.73 | KDM4E (0.66) | TP53CREBBP | |
| SCHEMBL12093313 | 0.73 | HTR6 (0.70) | HTR6 | |
| SCHEMBL13624634 | 0.72 | HTR6 (0.51) | HTR6 | |
| SCHEMBL5322539 | 0.71 | TP53 (1.00) | TP53CREBBP | |
| SCHEMBL30395130 | 0.71 | TP53 (1.00) | TP53CREBBP | |
| SCHEMBL7192965 | 0.71 | AGTR1 (0.55) | HTR6AGTR1 | |
| SCHEMBL2319772 | 0.71 | KDM4E (0.49) | TP53CREBBPHTR6PTGS1PTGS2 | |
| SCHEMBL14730819 | 0.70 | HTR6 (0.44) | HTR6AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622494-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-11-24 | — | — | US | disclosed |
| US-20090170923-A1 | HCV INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170923-A1 | HCV INHIBITORS | HAVCR2, MAVS, EIF2AK2 | TP53 2850/4885CREBBP 3006/4885HTR6 4552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.