Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | F11 | P03951 | 4/20 | 0.36 |
| ▸ | F2 | P00734 | 3/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 7/20 | 0.33 |
| ▸ | LPL | P06858 | 6/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15436345 | 0.86 | LIPG (0.37) | AAK1F11F2PRSS1PRSS2 | |
| SCHEMBL15092467 | 0.80 | F11 (0.40) | AAK1F11F2PRSS1PRSS2 | |
| SCHEMBL15092469 | 0.80 | F11 (0.40) | AAK1F11F2PRSS1PRSS2 | |
| SCHEMBL15436302 | 0.75 | LPL (0.37) | AAK1F11F2PRSS1PRSS2 | |
| SCHEMBL17289554 | 0.74 | F11 (0.42) | AAK1F11F2PRSS1PRSS2 | |
| SCHEMBL17289557 | 0.74 | F11 (0.42) | AAK1F11F2PRSS1PRSS2 | |
| SCHEMBL13953460 | 0.73 | LIPG (0.41) | AAK1F11F2PRSS1PRSS2 | |
| SCHEMBL13637092 | 0.72 | LIPG (0.40) | F11F2PRSS1PRSS2PRSS3 | |
| SCHEMBL23306187 | 0.72 | LIPG (0.45) | AAK1F11F2PRSS1PRSS2 | |
| SCHEMBL10254165 | 0.72 | LIPG (0.45) | AAK1F11F2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291371-B1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS INC (US) | 2015-06-10 | — | — | EP | disclosed |
| WO-2009134400-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |