Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.41 |
| ▸ | WNT3A | P56704 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL120004 | 0.88 | LMNA (0.44) | LMNAPTPN1ERCC5FEN1POLB | |
| SCHEMBL120003 | 0.88 | LMNA (0.44) | LMNAPTPN1ERCC5FEN1POLB | |
| SCHEMBL15979729 | 0.74 | PKM (0.62) | MEN1KMT2APTPN1ERCC5FEN1 | |
| SCHEMBL13517847 | 0.72 | KMT2A (0.56) | LMNAMEN1KMT2APTPN1POLB | |
| SCHEMBL31320755 | 0.71 | SIGMAR1 (0.63) | LMNAMEN1KMT2AHTR1ASMN1; SMN2 | |
| SCHEMBL5478440 | 0.71 | SMN1; SMN2 (0.53) | LMNAMEN1KMT2AHTR1AHTR7 | |
| SCHEMBL5478444 | 0.71 | SMN1; SMN2 (0.53) | LMNAMEN1KMT2AHTR1AHTR7 | |
| SCHEMBL30089515 | 0.71 | CTNNB1 (0.68) | MEN1KMT2APTPN1ERCC5FEN1 | |
| Hydrochloric Acid SCHEMBL22828990 | 0.70 | SIGMAR1 (0.61) | LMNAMEN1KMT2AHTR1ASMN1; SMN2 | |
| SCHEMBL9775157 | 0.69 | PTPN1 (0.57) | LMNAMEN1KMT2APTPN1ERCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134400-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |