Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15241489 | 0.91 | ALOX5 (0.36) | ALOX5MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL15241497 | 0.90 | ALOX5 (0.40) | ALOX5MEN1KMT2AFNTAFNTB | |
| SCHEMBL15436313 | 0.84 | CYP2C19 (0.40) | ALOX5MEN1KMT2ACNR1LMNA | |
| SCHEMBL13538362 | 0.84 | CYP2C19 (0.40) | ALOX5MEN1KMT2ACNR1LMNA | |
| SCHEMBL13953597 | 0.84 | ALOX5 (0.40) | ALOX5MEN1KMT2ACNR1LMNA | |
| SCHEMBL15241454 | 0.81 | ALOX5 (0.38) | ALOX5MEN1KMT2ACNR1LMNA | |
| SCHEMBL13624952 | 0.81 | ALOX5 (0.44) | ALOX5MEN1KMT2ACNR1LMNA | |
| SCHEMBL13552165 | 0.81 | ALDH1A1 (0.38) | ALOX5MEN1KMT2ACNR1LMNA | |
| SCHEMBL14865086 | 0.80 | CREBBP (0.40) | — | |
| SCHEMBL17120320 | 0.80 | ALOX5 (0.38) | ALOX5MEN1KMT2ACNR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687525-B1 | CYCLIC INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INT (DE) | 2015-09-23 | — | — | EP | disclosed |
| WO-2009134400-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |