Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2627172 | 0.82 | NPC1 (0.33) | MAPTMAPK1ALDH1A1TDP1 | |
| SCHEMBL13175588 | 0.72 | MAPT (0.40) | GAACASP1MAPTMAPK1ALDH1A1 | |
| SCHEMBL19943717 | 0.71 | AOC1 (0.35) | GAAMAPTALDH1A1TDP1 | |
| SCHEMBL7589418 | 0.66 | CASP1 (0.44) | GAACASP1MAPTMAPK1ALDH1A1 | |
| SCHEMBL12276331 | 0.66 | ALDH1A1 (0.41) | MAPTALDH1A1 | |
| SCHEMBL5027429 | 0.66 | PTGS1 (0.35) | MAPT | |
| Hydrochloric Acid SCHEMBL28937662 | 0.65 | CASP1 (0.42) | GAACASP1MAPTMAPK1ALDH1A1 | |
| SCHEMBL19511883 | 0.65 | MAPT (0.43) | GAACASP1MAPTMAPK1ALDH1A1 | |
| SCHEMBL784058 | 0.65 | PRKCI (0.53) | GAACASP1MAPTMAPK1ALDH1A1 | |
| SCHEMBL29380092 | 0.65 | MAPT (0.43) | GAACASP1MAPTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136995-A2 | INHIBITORS OF SYK PROTEIN KINASE | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |