Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | REN | P00797 | 15/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13625588 | 0.90 | REN (0.55) | RENKCNH2 | |
| SCHEMBL13625583 | 0.84 | REN (0.56) | RENKCNH2SLC6A2SLC6A4 | |
| SCHEMBL13625498 | 0.79 | REN (0.68) | RENKCNH2 | |
| SCHEMBL12837255 | 0.79 | REN (0.74) | RENKCNH2 | |
| SCHEMBL1518321 | 0.79 | REN (0.74) | RENKCNH2 | |
| SCHEMBL1518324 | 0.79 | REN (0.74) | RENKCNH2 | |
| SCHEMBL1518327 | 0.79 | REN (0.74) | RENKCNH2 | |
| SCHEMBL12764130 | 0.79 | REN (0.74) | RENKCNH2 | |
| SCHEMBL13625485 | 0.79 | REN (0.49) | SMN1; SMN2RENSLC6A2SLC6A4 | |
| SCHEMBL13625502 | 0.78 | REN (0.58) | SMN1; SMN2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |