Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 18/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13625578 | 0.84 | REN (0.67) | RENKCNH2 | |
| SCHEMBL13625580 | 0.84 | LMNA (0.52) | RENKCNH2SLC6A2SLC6A4 | |
| SCHEMBL13625498 | 0.84 | REN (0.68) | RENKCNH2 | |
| SCHEMBL13625588 | 0.81 | REN (0.55) | RENKCNH2 | |
| SCHEMBL1518355 | 0.78 | REN (0.85) | RENKCNH2 | |
| SCHEMBL12837195 | 0.78 | REN (0.85) | RENKCNH2 | |
| SCHEMBL12764156 | 0.78 | REN (0.85) | RENKCNH2 | |
| SCHEMBL1518353 | 0.78 | REN (0.85) | RENKCNH2 | |
| SCHEMBL1518349 | 0.78 | REN (0.85) | RENKCNH2 | |
| SCHEMBL13625579 | 0.75 | REN (0.67) | RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |