Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 4/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 4/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 4/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5027223 | 0.85 | PDK1 (0.41) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL11303094 | 0.84 | MEN1 (0.44) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL23886321 | 0.83 | ALDH1A1 (0.40) | PDK1PDK2PDK3PDK4HSP90AA1 | |
| SCHEMBL30018083 | 0.83 | ALDH1A1 (0.40) | PDK1PDK2PDK3PDK4HSP90AA1 | |
| SCHEMBL23260530 | 0.78 | ALDH1A1 (0.39) | ALDH1A1POLBHTTMAPK1KMT2A | |
| SCHEMBL2390487 | 0.77 | KCNN4 (0.44) | HSP90AA1HSP90AB1ALDH1A1LMNAHTT | |
| SCHEMBL3823022 | 0.77 | ALDH1A1 (0.52) | ALDH1A1POLBLMNAHTTKMT2A | |
| SCHEMBL29675910 | 0.75 | KMT2A (0.49) | PDK1PDK2PDK3PDK4HSP90AA1 | |
| SCHEMBL2364652 | 0.74 | ALDH1A1 (0.38) | ALDH1A1POLBLMNAHTTMEN1 | |
| SCHEMBL8167395 | 0.72 | CES2 (0.41) | PDK1PDK2PDK3PDK4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009138440-A1 | CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-11-19 | — | — | WO | disclosed |