SCHEMBL2364652

SCHEMBL2364652

CCC(NC(C)=O)(C(=O)O)c1ccccc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
RECQL P46063 1/20 0.38
OPRK1 P41145 2/20 0.37
KCNH2 Q12809 2/20 0.37
CHRM2 P08172 1/20 0.37
CYP2D6 P10635 1/20 0.37
CHRM1 P11229 1/20 0.37
ADRA2C P18825 1/20 0.37
CHRM3 P20309 1/20 0.37
SLC6A2 P23975 1/20 0.37
SLC6A4 P31645 1/20 0.37
OPRM1 P35372 1/20 0.37
HRH3 Q9Y5N1 1/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
HTT P42858 1/20 0.35
HTR2A P28223 1/20 0.35
HTR2C P28335 1/20 0.35
ADRA1A P35348 1/20 0.35
KIF11 P52732 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2364868 0.88 KMT2A (0.38) ALDH1A1RECQLHPGDMEN1KMT2A
SCHEMBL23700759 0.84 OPRK1 (0.38) ALDH1A1OPRK1KCNH2CHRM2CYP2D6
SCHEMBL2364635 0.79 KMT2A (0.49) ALDH1A1RECQLNPC1HPGDMEN1
SCHEMBL878148 0.79 ALDH1A1 (0.38) ALDH1A1OPRK1KCNH2CHRM2CYP2D6
SCHEMBL9829583 0.79 CXCR2 (0.42) ALDH1A1RECQLCYP2D6HTTKIF11
SCHEMBL9829581 0.79 CXCR2 (0.42) ALDH1A1RECQLCYP2D6HTTKIF11
SCHEMBL2364807 0.78 ALDH1A1 (0.37) ALDH1A1RECQLCYP2D6CHRM1HPGD
SCHEMBL2365010 0.77 L3MBTL1 (0.50) ALDH1A1RECQLADRA2CRAB9AMEN1
SCHEMBL13626302 0.74 PDK1 (0.41) ALDH1A1NPC1RAB9AHTTHPGD
SCHEMBL2364591 0.73 NFE2L2 (0.41) ALDH1A1NPC1RAB9AHPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011092284-A1 NOVEL AMINO ACID DERIVATIVES AND THEIR USE AS GPR43 RECEPTOR MODULATORS EUROSCREEN S.A. (BE) 2011-08-04 WO disclosed