Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LHCGR | P22888 | 4/20 | 0.39 |
| ▸ | F10 | P00742 | 6/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 2/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626484 | 0.87 | CFTR (0.49) | F10CFTR | |
| SCHEMBL13626481 | 0.87 | CFTR (0.49) | F10CFTR | |
| SCHEMBL13626490 | 0.87 | CFTR (0.49) | F10CFTR | |
| SCHEMBL13626536 | 0.84 | F10 (0.42) | F10CFTR | |
| SCHEMBL13626522 | 0.83 | CFTR (0.40) | F10TRPV1CFTR | |
| SCHEMBL13626532 | 0.83 | SMN1; SMN2 (0.45) | F10CFTR | |
| SCHEMBL3828864 | 0.80 | CCR1 (0.53) | CCR1 | |
| SCHEMBL13626540 | 0.79 | F10 (0.47) | LHCGRF10 | |
| SCHEMBL13626543 | 0.79 | CFTR (0.41) | LHCGRF10CFTRCCR1 | |
| SCHEMBL8282298 | 0.78 | F10 (0.57) | F10CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |