Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 8/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | LHCGR | P22888 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626503 | 0.86 | CFTR (0.56) | CFTRF10LMNAPKM | |
| SCHEMBL13626534 | 0.82 | CFTR (0.49) | CFTRF10 | |
| SCHEMBL13626527 | 0.82 | CFTR (0.46) | CFTRF10LMNAPKMCCR1 | |
| SCHEMBL13626535 | 0.79 | LHCGR (0.39) | CFTRF10LHCGRCCR1 | |
| SCHEMBL13626540 | 0.78 | F10 (0.47) | F10LHCGRLMNA | |
| SCHEMBL8282294 | 0.77 | F10 (0.55) | F10CCR1 | |
| SCHEMBL13626501 | 0.71 | CFTR (0.59) | CFTRLMNAPKM | |
| SCHEMBL13626492 | 0.70 | CFTR (0.55) | CFTRF10LMNAPKM | |
| SCHEMBL13626525 | 0.68 | CFTR (0.45) | CFTRLMNAPKM | |
| SCHEMBL13626533 | 0.68 | SMN1; SMN2 (0.49) | CFTRF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |