Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626536 | 0.88 | F10 (0.42) | CFTRMAPTKMT2AF10 | |
| SCHEMBL13626481 | 0.87 | CFTR (0.49) | CFTRMAPTKMT2AF10 | |
| SCHEMBL13626490 | 0.87 | CFTR (0.49) | CFTRMAPTKMT2AF10 | |
| SCHEMBL13626484 | 0.87 | CFTR (0.49) | CFTRMAPTKMT2AF10 | |
| SCHEMBL13626535 | 0.83 | LHCGR (0.39) | CFTRF10 | |
| SCHEMBL13626522 | 0.82 | CFTR (0.40) | CFTRKMT2AF10 | |
| SCHEMBL13626534 | 0.79 | CFTR (0.49) | SMN1; SMN2CFTRMAPTF10 | |
| SCHEMBL3828864 | 0.79 | CCR1 (0.53) | TSHR | |
| SCHEMBL13626533 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2CFTRMAPTPDE4BF10 | |
| SCHEMBL8282298 | 0.77 | F10 (0.57) | MAPTKMT2AF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |