Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 7/20 | 0.40 |
| ▸ | F10 | P00742 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626490 | 0.89 | CFTR (0.49) | CFTRF10MEN1GAAKMT2A | |
| SCHEMBL13626481 | 0.89 | CFTR (0.49) | CFTRF10MEN1GAAKMT2A | |
| SCHEMBL13626484 | 0.89 | CFTR (0.49) | CFTRF10MEN1GAAKMT2A | |
| SCHEMBL13626535 | 0.83 | LHCGR (0.39) | CFTRF10TRPV1 | |
| SCHEMBL13626536 | 0.83 | F10 (0.42) | CFTRF10MEN1GAAKMT2A | |
| SCHEMBL13626532 | 0.82 | SMN1; SMN2 (0.45) | CFTRF10KMT2A | |
| SCHEMBL13626542 | 0.80 | F10 (0.43) | F10MEN1GAAKMT2ATAS1R3 | |
| SCHEMBL13626527 | 0.79 | CFTR (0.46) | CFTRF10MEN1GAAKMT2A | |
| SCHEMBL3828864 | 0.79 | CCR1 (0.53) | — | |
| SCHEMBL13626525 | 0.78 | CFTR (0.45) | CFTRMEN1GAAKMT2ATAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |