Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 6/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 8/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626484 | 0.90 | CFTR (0.49) | F10CFTRMEN1GAAKMT2A | |
| SCHEMBL13626481 | 0.90 | CFTR (0.49) | F10CFTRMEN1GAAKMT2A | |
| SCHEMBL13626490 | 0.90 | CFTR (0.49) | F10CFTRMEN1GAAKMT2A | |
| SCHEMBL13626532 | 0.88 | SMN1; SMN2 (0.45) | F10CFTRKMT2AMAPT | |
| SCHEMBL13626535 | 0.84 | LHCGR (0.39) | F10CFTR | |
| SCHEMBL13626522 | 0.83 | CFTR (0.40) | F10CFTRMEN1GAAKMT2A | |
| SCHEMBL3828864 | 0.80 | CCR1 (0.53) | — | |
| SCHEMBL8282298 | 0.78 | F10 (0.57) | F10MEN1KMT2AMAPT | |
| SCHEMBL13626555 | 0.78 | F10 (0.49) | F10CFTRLMNA | |
| SCHEMBL13626499 | 0.78 | CFTR (0.48) | CFTRMEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |