Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626486 | 0.85 | CFTR (0.50) | LMNATAS1R3TAS1R1TAS1R2CFTR | |
| SCHEMBL13626544 | 0.77 | TAS1R3 (0.43) | TAS1R3TAS1R1TAS1R2XIAPCFTR | |
| SCHEMBL6102700 | 0.77 | DRD4 (0.56) | LMNATP53TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL28462243 | 0.67 | CYP1A2 (0.44) | LMNAHTR1ADRD2HTR2AHTR2C | |
| SCHEMBL5303965 | 0.66 | MAPT (0.52) | LMNAMAPTMEN1GAAKMT2A | |
| SCHEMBL13626490 | 0.63 | CFTR (0.49) | LMNATAS1R3TAS1R1TAS1R2CFTR | |
| SCHEMBL13626481 | 0.63 | CFTR (0.49) | LMNATAS1R3TAS1R1TAS1R2CFTR | |
| SCHEMBL13626484 | 0.63 | CFTR (0.49) | LMNATAS1R3TAS1R1TAS1R2CFTR | |
| SCHEMBL4516247 | 0.63 | LMNA (0.49) | LMNATP53XIAP | |
| SCHEMBL14507137 | 0.62 | LMNA (0.49) | LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |