Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 2/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | LHCGR | P22888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626486 | 0.85 | CFTR (0.50) | TAS1R3TAS1R1TAS1R2MEN1KMT2A | |
| SCHEMBL13626542 | 0.78 | F10 (0.43) | TAS1R3TAS1R1TAS1R2MEN1KMT2A | |
| SCHEMBL13626548 | 0.77 | LMNA (0.46) | TAS1R3TAS1R1TAS1R2MEN1KMT2A | |
| SCHEMBL4606642 | 0.76 | F10 (0.54) | TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL4605212 | 0.76 | F10 (0.54) | TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13626545 | 0.75 | F10 (0.49) | TAS1R3TAS1R1TAS1R2MEN1KMT2A | |
| SCHEMBL4604029 | 0.72 | F10 (0.42) | TAS1R3TAS1R1TAS1R2MEN1KMT2A | |
| SCHEMBL4606187 | 0.72 | F10 (0.42) | TAS1R3TAS1R1TAS1R2MEN1KMT2A | |
| SCHEMBL14507138 | 0.72 | F10 (0.54) | TAS1R3TAS1R1TAS1R2MEN1KMT2A | |
| SCHEMBL13626546 | 0.72 | F10 (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |