Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 12/20 | 0.46 |
| ▸ | CFTR | P13569 | 6/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626556 | 0.91 | F10 (0.55) | F10CFTR | |
| SCHEMBL13626553 | 0.82 | F10 (0.61) | F10CFTR | |
| SCHEMBL13626552 | 0.82 | F10 (0.61) | F10CFTR | |
| SCHEMBL13626555 | 0.77 | F10 (0.49) | F10CFTR | |
| SCHEMBL4605676 | 0.74 | F10 (0.76) | F10 | |
| SCHEMBL4604418 | 0.74 | F10 (0.78) | F10 | |
| SCHEMBL4606847 | 0.74 | F10 (0.78) | F10 | |
| SCHEMBL13626565 | 0.73 | F10 (0.56) | F10CFTR | |
| SCHEMBL13626536 | 0.73 | F10 (0.42) | F10CFTRPRSS1 | |
| SCHEMBL13626567 | 0.71 | F10 (0.52) | F10CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |