Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 16/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4241541 | 1.00 | P2RX7 (0.39) | P2RX7HTR2CEPHX2GAAHTT | |
| SCHEMBL4481959 | 1.00 | P2RX7 (0.39) | P2RX7HTR2CEPHX2GAAHTT | |
| SCHEMBL4477909 | 0.88 | P2RX7 (0.38) | P2RX7HTR2CEPHX2HTT | |
| SCHEMBL4480936 | 0.88 | P2RX7 (0.38) | P2RX7HTR2CEPHX2HTT | |
| SCHEMBL13627347 | 0.88 | P2RX7 (0.38) | P2RX7HTR2CEPHX2HTT | |
| SCHEMBL4489439 | 0.83 | HTR2C (0.38) | HTR2C | |
| SCHEMBL13627333 | 0.83 | HTR2C (0.38) | HTR2C | |
| SCHEMBL4492625 | 0.81 | CHRNB2 (0.40) | HTR2CGAAHTT | |
| SCHEMBL13627337 | 0.81 | CHRNB2 (0.40) | HTR2CGAAHTT | |
| SCHEMBL13627340 | 0.79 | GAA (0.38) | P2RX7HTR2CEPHX2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |