Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.67 |
| ▸ | KMO | O15229 | 2/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1035363 | 0.88 | KMO (0.57) | PARP1KMOCTSSKDM4EKDM1A | |
| SCHEMBL13854087 | 0.82 | CTSS (0.58) | KMOCTSSKDM4EKDM1AXDH | |
| SCHEMBL1034065 | 0.81 | RXFP1 (0.53) | PARP1 | |
| SCHEMBL6442515 | 0.81 | PARP1 (1.00) | PARP1KDM4E | |
| SCHEMBL31061508 | 0.81 | PARP1 (1.00) | PARP1KDM4E | |
| SCHEMBL1034305 | 0.80 | KMO (0.49) | PARP1KMO | |
| SCHEMBL17772322 | 0.80 | KMO (0.44) | PARP1KMOCTSSKDM4EKDM1A | |
| SCHEMBL1032856 | 0.80 | KDM1A (0.50) | PARP1KMOCTSSKDM4EKDM1A | |
| SCHEMBL1034072 | 0.79 | JAK2 (0.51) | KMOJAK2 | |
| SCHEMBL27830698 | 0.79 | ALDH1A1 (0.54) | PARP1KMOKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134973-A1 | QUENOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |