Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | UBE2N | P61088 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | CES1 | P23141 | 3/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7611051 | 0.88 | ALDH1A1 (0.66) | LMNACASP3ALDH1A1MAPTLRRK2 | |
| SCHEMBL7611054 | 0.88 | ALDH1A1 (0.66) | LMNACASP3ALDH1A1MAPTLRRK2 | |
| SCHEMBL13627881 | 0.87 | CES1 (0.67) | LMNAALDH1A1MAPTLRRK2PKM | |
| SCHEMBL13627937 | 0.86 | CHRM5 (0.55) | LMNAHPGDUBE2NATML3MBTL1 | |
| SCHEMBL13627880 | 0.86 | ALDH1A1 (0.70) | LMNAALDH1A1MAPTLRRK2PKM | |
| SCHEMBL13627897 | 0.85 | UBE2N (0.63) | LMNAHPGDUBE2NATML3MBTL1 | |
| SCHEMBL13627936 | 0.84 | TRPA1 (0.62) | ALDH1A1MAPTLRRK2PKMTSHR | |
| SCHEMBL13627950 | 0.83 | MAPT (0.59) | LMNAL3MBTL1CASP3ALDH1A1MAPT | |
| SCHEMBL13627928 | 0.83 | ALDH3A1 (0.51) | LMNAHPGDUBE2NATML3MBTL1 | |
| SCHEMBL13627878 | 0.83 | ALDH1A1 (0.70) | LMNAALDH1A1MAPTLRRK2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612065-B2 | Inhibitors of c-JUN N-terminal kinases (JNK) | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612065-B2 | Inhibitors of c-JUN N-terminal kinases (JNK) | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-11-03 | — | — | US | disclosed |
| EP-1175399-B1 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) | VERTEX PHARMA (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20080033022-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) | SALITURO FRANCESCO G | 2008-02-07 | — | — | US | disclosed |
| US-20080033022-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) | SALITURO FRANCESCO G | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080033022-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) | MAP3K1, JUN, MAP3K7 | LMNA 2123/4885HPGD 1551/4885UBE2N 1915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.