Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 7/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 6/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628514 | 0.88 | HTR7 (0.39) | CYP2D6HTR7NOS2ADRA1DHTR2C | |
| SCHEMBL13628525 | 0.82 | CYP2D6 (0.57) | CYP2D6 | |
| SCHEMBL13628672 | 0.69 | CYP2D6 (0.55) | CYP2D6 | |
| SCHEMBL7459147 | 0.68 | NOS2 (0.66) | CYP2D6NOS2 | |
| SCHEMBL2642666 | 0.67 | KCNH2 (0.41) | NOS2MAPK14ASIC3 | |
| SCHEMBL24685616 | 0.65 | SLC6A4 (0.44) | CYP2D6NOS2HTR2C | |
| SCHEMBL291729 | 0.65 | CYP2D6 (0.60) | CYP2D6 | |
| SCHEMBL291728 | 0.65 | CYP2D6 (0.60) | CYP2D6 | |
| SCHEMBL2642869 | 0.65 | — | — | |
| SCHEMBL13280631 | 0.64 | LRRK2 (0.50) | CYP2D6HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612197-B2 | Reacting a nucleophil with OH group with an electrophil to form an adduct, reacting adduct with a reagent selected from oxidizing, sulfurizing or selenizing agents to produce hydroxy protected oligonucleotide, heating to deprotect hydroxy protecting group such as 2-(2-pyridyl)aminoethoxycarbonyl | The United States of America as repesented by the Secretary of the Department of Health and Human Services (US) | 2009-11-03 | — | — | US | disclosed |