Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.43 |
| ▸ | FABP1 | P07148 | 1/20 | 0.43 |
| ▸ | FABP6 | P51161 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628525 | 0.86 | CYP2D6 (0.57) | CYP2D6FDPSPCSK9FABP1FABP6 | |
| SCHEMBL13628514 | 0.83 | HTR7 (0.39) | CYP2D6 | |
| SCHEMBL291728 | 0.76 | CYP2D6 (0.60) | CYP2D6FDPSFABP1FABP6POLB | |
| SCHEMBL13628670 | 0.76 | CYP1A2 (0.46) | KDM4EALDH1A1CYP2C19CYP1A2NPC1 | |
| SCHEMBL291729 | 0.76 | CYP2D6 (0.60) | CYP2D6FDPSFABP1FABP6POLB | |
| SCHEMBL4281005 | 0.75 | CYP2D6 (0.72) | CYP2D6FDPSPCSK9FABP1FABP6 | |
| SCHEMBL7448193 | 0.73 | CYP2D6 (0.59) | CYP2D6FDPSPCSK9FABP1FABP6 | |
| SCHEMBL13628956 | 0.73 | CYP2D6 (0.37) | CYP2D6POLBKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL10830140 | 0.71 | CYP2D6 (0.53) | CYP2D6FDPSPCSK9FABP1FABP6 | |
| Phenyramidol SCHEMBL21963 | 0.71 | CYP2D6 (1.00) | CYP2D6FDPSFABP1FABP6CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612197-B2 | Reacting a nucleophil with OH group with an electrophil to form an adduct, reacting adduct with a reagent selected from oxidizing, sulfurizing or selenizing agents to produce hydroxy protected oligonucleotide, heating to deprotect hydroxy protecting group such as 2-(2-pyridyl)aminoethoxycarbonyl | The United States of America as repesented by the Secretary of the Department of Health and Human Services (US) | 2009-11-03 | — | — | US | disclosed |