Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HRH1 | P35367 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13628513 | 0.86 | CYP2D6 (0.39) | CYP2D6CYP2C19CHRM2SLC6A4SLC6A2 | |
| SCHEMBL13628673 | 0.84 | ASIC3 (0.32) | ADRA2AADRA2BADRA2CAOC3 | |
| SCHEMBL291511 | 0.77 | PPARG (0.41) | CYP2D6CYP2C19PPARGLMNAKDM4E | |
| SCHEMBL13628670 | 0.74 | CYP1A2 (0.46) | CYP2C19SLC6A4SLC6A2HRH1LMNA | |
| SCHEMBL5779464 | 0.73 | CYP2D6 (0.50) | CYP2D6CYP2C19CHRM2SLC6A4SLC6A2 | |
| SCHEMBL13628672 | 0.73 | CYP2D6 (0.55) | CYP2D6CYP2C19KDM4ESMN1; SMN2GAA | |
| SCHEMBL4339397 | 0.73 | AOC3 (0.53) | CYP2D6CYP2C19CHRM2SLC6A4SLC6A2 | |
| SCHEMBL13628675 | 0.72 | MAPT (0.46) | CYP2D6CYP2C19CHRM2SLC6A4SLC6A2 | |
| SCHEMBL14224120 | 0.69 | TACR1 (0.43) | LMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL28987136 | 0.66 | TSHR (0.50) | CYP2D6CYP2C19CHRM2SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612197-B2 | Reacting a nucleophil with OH group with an electrophil to form an adduct, reacting adduct with a reagent selected from oxidizing, sulfurizing or selenizing agents to produce hydroxy protected oligonucleotide, heating to deprotect hydroxy protecting group such as 2-(2-pyridyl)aminoethoxycarbonyl | The United States of America as repesented by the Secretary of the Department of Health and Human Services (US) | 2009-11-03 | — | — | US | disclosed |