Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | KIF11 | P52732 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5450074 | 0.83 | ESR1 (0.44) | KIF11ALDH1A1TSHRMAPK1CYP3A4 | |
| SCHEMBL29441583 | 0.81 | HDAC4 (0.47) | CYP19A1KIF11ALDH1A1TSHRSCN5A | |
| SCHEMBL78619 | 0.81 | HDAC4 (0.47) | CYP19A1KIF11ALDH1A1TSHRSCN5A | |
| SCHEMBL8137247 | 0.81 | ESR1 (0.50) | CYP19A1KIF11ALDH1A1TSHRSCN5A | |
| Water SCHEMBL5694439 | 0.80 | ESR1 (0.43) | KIF11ALDH1A1TSHRMAPK1CYP3A4 | |
| SCHEMBL8633370 | 0.79 | CYP19A1 (0.43) | CYP19A1KIF11ALDH1A1TSHRSCN5A | |
| SCHEMBL11469047 | 0.79 | CYP19A1 (0.43) | CYP19A1KIF11ALDH1A1TSHRSCN5A | |
| SCHEMBL12811806 | 0.79 | ALDH1A1 (0.43) | CYP19A1KIF11ALDH1A1TSHRSCN5A | |
| Hydrogen Peroxide SCHEMBL29076072 | 0.78 | ESR1 (0.46) | ALDH1A1MAPK1CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7035573 | 0.77 | CYP19A1 (0.42) | CYP19A1KIF11ALDH1A1TSHRSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | disclosed |
| US-20080167371-A1 | Diaryl, Dipyridinyl and Aryl-Pyridinyl Derivatives and Uses Thereof | PFIZER INC. | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167371-A1 | Diaryl, Dipyridinyl and Aryl-Pyridinyl Derivatives and Uses Thereof | OPRD1, OPRK1, OPRL1 | CYP19A1 650/4885KIF11 4652/4885ALDH1A1 1390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.