SCHEMBL13633506

SCHEMBL13633506

O=C(Nc1cn2c(COC3CCCCO3)cc(Br)cc2n1)C(F)(F)F

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CREBBP Q92793 2/20 0.34
EP300 Q09472 1/20 0.34
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.30
ICAM1 P05362 1/20 0.30
SELE P16581 1/20 0.30
KDM4C Q9H3R0 1/20 0.30
TGFBR1 P36897 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13633498 0.86
SCHEMBL13633454 0.78 KDM4C (0.35) L3MBTL1ICAM1SELEKDM4C
SCHEMBL13633456 0.77 MAP3K5 (0.31)
SCHEMBL13633497 0.62 MAP3K5 (0.40) L3MBTL1
SCHEMBL3411723 0.62 MEN1 (0.39) CREBBPEP300MEN1KMT2AL3MBTL1
SCHEMBL7106376 0.60 PDK1 (0.43) CREBBPMEN1KMT2AL3MBTL1KDM4C
SCHEMBL7106372 0.60 PDK1 (0.43) CREBBPMEN1KMT2AL3MBTL1KDM4C
SCHEMBL19736987 0.60 KDM4C (0.35) CREBBPEP300L3MBTL1ICAM1SELE
SCHEMBL3146252 0.60 KDM4E (0.39)
SCHEMBL10499836 0.59 EPHX2 (0.45) MEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090275577-A1 IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS PFIZER INC 2009-11-05 US disclosed
US-7563788-B2 Substituted Imidazo[1,2-a]pyridines as Antibacterial Agents PFIZER INC. (US) 2009-07-21 US disclosed
US-20070191394-A1 Antibacterial agents WARNER-LAMBERT COMPANY LLC 2007-08-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070191394-A1 Antibacterial agents MRPL21, RPN2, FBL CREBBP 3010/4885EP300 2378/4885MEN1 2732/4885
US-20090275577-A1 IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS DPYD, TYMP, ITPA CREBBP 1776/4885EP300 1878/4885MEN1 3353/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.