Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1361309 | 0.82 | HTR1A (0.62) | DRD2HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL1360412 | 0.82 | HTR1A (0.62) | DRD2HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL4825520 | 0.82 | FYN (0.48) | DRD2DRD4DRD3CYP19A1 | |
| SCHEMBL8365487 | 0.82 | FYN (0.48) | DRD2DRD4DRD3CYP19A1 | |
| SCHEMBL8074280 | 0.77 | DRD2 (0.83) | DRD2DRD4DRD3MTNR1AMTNR1B | |
| SCHEMBL8074250 | 0.77 | DRD2 (0.83) | DRD2DRD4DRD3MTNR1AMTNR1B | |
| SCHEMBL7543711 | 0.77 | DRD2 (0.83) | DRD2DRD4DRD3MTNR1AMTNR1B | |
| SCHEMBL4823619 | 0.76 | FYN (0.48) | DRD2DRD4DRD3CYP19A1 | |
| SCHEMBL14193287 | 0.76 | FYN (0.48) | DRD2DRD4DRD3CYP19A1 | |
| SCHEMBL14545524 | 0.76 | DRD2 (0.54) | DRD2HTR1AADRA1ADRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067410-B2 | Phenolic and catecholic amines and prodrugs thereof | H. LUNDBECK A/S (DK) | 2011-11-29 | — | — | US | disclosed |
| US-8067410-B2 | Phenolic and catecholic amines and prodrugs thereof | H. LUNDBECK A/S (DK) | 2011-11-29 | — | — | US | disclosed |
| US-8067410-B2 | Phenolic and catecholic amines and prodrugs thereof | H. LUNDBECK A/S (DK) | 2011-11-29 | — | — | US | disclosed |
| US-20090325946-A1 | NOVEL PHENOLIC AND CATECHOLIC AMINES AND PRODRUGS THEREOF | H. LUNDBECK A/S (DK) | 2009-12-31 | — | — | US | disclosed |
| US-20090325946-A1 | NOVEL PHENOLIC AND CATECHOLIC AMINES AND PRODRUGS THEREOF | H. LUNDBECK A/S (DK) | 2009-12-31 | — | — | US | disclosed |
| WO-2009156458-A1 | NOVEL PHENOLIC AND CATECHOLIC AMINES AND PRODRUGS THEREOF | H. LUNDBECK A/S (DK) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325946-A1 | NOVEL PHENOLIC AND CATECHOLIC AMINES AND PRODRUGS THEREOF | COMT, PNMT, TYR | DRD2 210/4885HTR1A 101/4885ADRA2A 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.