Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12161602 | 0.91 | KMT2A (0.41) | ALDH1A1HPGDKMT2ACASP1GAA | |
| SCHEMBL9922213 | 0.88 | CA12 (0.36) | KMT2AGAAP2RY12MEN1APP | |
| SCHEMBL14228254 | 0.87 | FPR2 (0.36) | KMT2AP2RY12MEN1NLRP3CA12 | |
| SCHEMBL9922401 | 0.87 | NLRP3 (0.39) | ALDH1A1HPGDKMT2ACASP1GAA | |
| SCHEMBL13638706 | 0.87 | MEN1 (0.36) | ALDH1A1HPGDKMT2AGAAL3MBTL1 | |
| SCHEMBL9922209 | 0.86 | CA12 (0.36) | KMT2AGAAKDM4EP2RY12MEN1 | |
| SCHEMBL9922182 | 0.86 | CA12 (0.33) | P2RY12NLRP3CA12CA1CA2 | |
| SCHEMBL9922214 | 0.86 | FBP1 (0.36) | P2RY12NLRP3CA12CA1CA2 | |
| SCHEMBL12177301 | 0.86 | CA12 (0.33) | P2RY12CA12CA1CA2CA9 | |
| SCHEMBL12161605 | 0.85 | P2RY12 (0.32) | P2RY12NLRP3CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622474-B2 | Asulfonyl(urea, thiourea, guanidine, cyanoguanidine) compounds; cardiovascular disorders; thrombosis | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-24 | — | — | US | disclosed |