Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL495726 | 0.99 | SIRT6 (0.54) | SIRT6ALDH1A1LMNAL3MBTL1MAPT | |
| SCHEMBL378383 | 0.90 | SIRT6 (0.65) | SIRT6ALDH1A1LMNAL3MBTL1MAPT | |
| SCHEMBL1887396 | 0.90 | L3MBTL1 (0.52) | SIRT6ALDH1A1LMNAL3MBTL1MAPT | |
| SCHEMBL13161883 | 0.90 | ALDH1A1 (0.50) | SIRT6ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL2771503 | 0.89 | SMN1; SMN2 (0.53) | SIRT6ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL13161884 | 0.89 | KDM4E (0.52) | SIRT6ALDH1A1LMNAL3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL378382 | 0.89 | SIRT6 (0.64) | SIRT6ALDH1A1LMNAL3MBTL1MAPT | |
| SCHEMBL590915 | 0.89 | L3MBTL1 (0.53) | SIRT6ALDH1A1LMNAL3MBTL1MAPT | |
| SCHEMBL13634261 | 0.88 | SIRT6 (0.51) | SIRT6ALDH1A1LMNAL3MBTL1MAPT | |
| SCHEMBL13634263 | 0.88 | SIRT6 (0.51) | SIRT6ALDH1A1LMNAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206707-B1 | AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2014-07-23 | — | — | EP | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |