Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 13/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634374 | 0.84 | ALDH1A1 (0.43) | SIRT6MAPTALDH1A1HTTHPGD | |
| SCHEMBL5624466 | 0.82 | SIRT6 (0.76) | SIRT6MAPTALDH1A1CYP2C19CYP2C9 | |
| SCHEMBL13634403 | 0.82 | DRD4 (0.47) | SIRT6MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL20509684 | 0.78 | SIRT6 (0.81) | SIRT6MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL44878 | 0.77 | SIRT6 (0.79) | SIRT6MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL21682911 | 0.77 | SIRT6 (0.74) | SIRT6MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL20509923 | 0.77 | SIRT6 (0.64) | SIRT6MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL15888639 | 0.76 | SIRT6 (0.60) | SIRT6MAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL22652232 | 0.76 | SIRT6 (1.00) | SIRT6MAPTALDH1A1MAPK1 | |
| SCHEMBL31438048 | 0.76 | MEN1 (0.50) | SIRT6MAPTALDH1A1MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |