Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 7/20 | 0.32 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15888552 | 0.82 | NLRP3 (0.40) | NAPEPLDCREBBPCHRM4CNR2ACACB | |
| SCHEMBL13163116 | 0.81 | GNE (0.40) | ITGALIRAK4 | |
| SCHEMBL3436256 | 0.79 | GNE (0.39) | IRAK4 | |
| SCHEMBL13162795 | 0.77 | LRRK2 (0.32) | CREBBPCHRM4GRIA1FFAR2LRRK2 | |
| SCHEMBL13634369 | 0.74 | LRRK2 (0.33) | CREBBPCHRM4CNR2LRRK2 | |
| SCHEMBL13634345 | 0.73 | PTGER1 (0.45) | — | |
| SCHEMBL13162585 | 0.73 | IRAK4 (0.37) | ITGALIRAK4 | |
| SCHEMBL2079853 | 0.72 | KMO (0.49) | IRAK4 | |
| SCHEMBL17373753 | 0.71 | GSK3B (0.45) | ITGALIRAK4 | |
| SCHEMBL18207851 | 0.70 | IRAK4 (0.47) | ITGALIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206707-B1 | AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2014-07-23 | — | — | EP | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |