Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13634699 | 0.86 | IRAK4 (0.50) | IRAK4JAK2JAK1GRM2MAPT | |
| SCHEMBL13634721 | 0.84 | IRAK4 (0.49) | IRAK4JAK2JAK1ALDH1A1AKT1 | |
| SCHEMBL13634720 | 0.84 | IRAK4 (0.47) | IRAK4JAK2JAK1KMT2AMEN1 | |
| SCHEMBL13634550 | 0.83 | IRAK4 (0.46) | IRAK4JAK2JAK1GRM2F10 | |
| SCHEMBL13638816 | 0.83 | IRAK4 (0.46) | IRAK4JAK2JAK1KMT2AMEN1 | |
| SCHEMBL13634362 | 0.82 | CCNE2 (0.48) | JAK2JAK1KMT2AALDH1A1HTT | |
| SCHEMBL2770583 | 0.82 | F10 (0.49) | IRAK4KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2771393 | 0.81 | F10 (0.48) | IRAK4KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13634878 | 0.80 | IRAK4 (0.43) | IRAK4JAK2JAK1GRM2PIK3CA | |
| SCHEMBL13634581 | 0.80 | ACKR3 (0.42) | IRAK4SMN1; SMN2ACKR3AURKACDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |
| US-8304547-B2 | Azolecarboxamide compound or salt thereof | ASTELLAS PHARMA INC. (JP) | 2012-11-06 | — | — | US | disclosed |