Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RORA | P35398 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | RORB | Q92753 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13635044 | 0.89 | ALDH1A1 (0.37) | ALDH1A1GAAKMT2AKDM4EHTT | |
| SCHEMBL4392246 | 0.84 | LCK (0.42) | LCKALDH1A1GAALMNAKMT2A | |
| SCHEMBL13983680 | 0.83 | LCK (0.41) | LCKALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL13635043 | 0.80 | HSD11B1 (0.44) | RORCHSD11B1 | |
| SCHEMBL13983681 | 0.72 | LCK (0.42) | LCKALDH1A1GAAKMT2AKDM4E | |
| SCHEMBL13983677 | 0.71 | RORA (0.48) | LCKRORARORCRORB | |
| SCHEMBL4378568 | 0.71 | ALDH1A1 (0.43) | LCKALDH1A1GAAKMT2AKDM4E | |
| SCHEMBL4384504 | 0.70 | RORA (0.52) | LCKALDH1A1KMT2AKDM4EHTT | |
| SCHEMBL13985956 | 0.64 | HSD11B1 (0.46) | LCKHSD11B1 | |
| SCHEMBL12645426 | 0.64 | HSD11B1 (0.51) | ALDH1A1GAALMNAKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893609-B1 | N-(PYRIDIN-2-YL)-SULFONAMIDE DERIVATIVES | PFIZER (US) | 2009-11-18 | — | — | EP | disclosed |